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Updated: Jul 30, 2026
09:47
Microdissection of Black Widow Spider Silk-producing Glands
Published on: January 11, 2011
Persistent painful plaque due to a brown recluse spider bite
1Mayo Clinic, Scottsdale, Arizona 85259.
Cutis
|October 1, 1992
Summary
Brown recluse spider bites can cause skin damage. This case highlights unusual hyalinizing panniculitis and myonecrosis in a chronic, painful skin plaque from a Loxosceles bite.
Area of Science:
- Dermatology
- Toxicology
- Pathology
Background:
- Loxosceles spider bites are known to cause various cutaneous reactions, including hemorrhage, necrosis, and inflammation.
- Typical Loxosceles envenomation involves dermal and subdermal tissue damage due to venom components.
Observation:
- A patient presented with a chronic, painful skin plaque attributed to a brown recluse spider bite.
- The lesion persisted and exhibited atypical clinical features.
Findings:
- Histopathological examination revealed unusual findings of cutaneous and deep subcutaneous hyalinizing panniculitis.
- Significant myonecrosis was also observed, indicating deep tissue involvement.
Implications:
- This case expands the known spectrum of histopathological presentations of Loxosceles envenomation.
- Recognizing these unusual findings is crucial for accurate diagnosis and management of complex spider bite reactions.
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