Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intracranial hemodynamics in sleep apnea.

A Q Fischer1, B A Chaudhary, M A Taormina

  • 1International Institute of Neurosonology, University Hospital, Augusta, Georgia.

Chest
|November 1, 1992
PubMed
Summary

Severe sleep apnea syndrome (SAS) is linked to reduced cerebral blood flow velocities. Transcranial Doppler sonography reveals lower blood flow in SAS patients, suggesting its utility in evaluating this condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genotoxic and cytotoxic potential of Alternanthera Bettzickiana, an important ethno-medicinal plant.

Cellular and molecular biology (Noisy-le-Grand, France)·2017
Same author

Formulation and characterization of modified release tablets containing isoniazid using swellable polymers.

African journal of traditional, complementary, and alternative medicines : AJTCAM·2012
Same author

Sleep disorders: a risk factor for normal-tension glaucoma?

Journal of glaucoma·2001
Same author

Hour-to-hour variability of oxygen saturation in sleep apnea.

Chest·1998
Same author

Pleural thickening in mild kaolinosis.

Southern medical journal·1997
Same author

Therapy for sleep apnea: who should be treated with CPAP?

Journal of the Medical Association of Georgia·1997

Area of Science:

  • Neurology
  • Cardiovascular Science
  • Sleep Medicine

Background:

  • Sleep apnea syndrome (SAS) is associated with intracranial pressure changes and impaired cerebral perfusion.
  • Previous studies were limited by the lack of reliable noninvasive methods to assess cerebral blood flow.

Purpose of the Study:

  • To investigate cerebral blood flow velocities in patients with severe SAS compared to healthy controls.
  • To evaluate the utility of transcranial Doppler sonography in assessing cerebral hemodynamics in SAS.

Main Methods:

  • Utilized transcranial Doppler sonography to measure systolic, diastolic, and mean cerebral blood flow velocities of the middle cerebral artery.
  • Included 23 participants: 12 with severe SAS and 11 controls.
  • Measurements were taken before sleep, during NREM and REM sleep, and upon awakening.

Main Results:

  • Cerebral blood flow velocities (systolic, diastolic, mean) were significantly decreased in SAS patients compared to controls.
  • Mean and systolic velocities showed significant reductions (p = 0.033 and p = 0.005, respectively).
  • SAS patients exhibited higher end-tidal CO2 levels (47.3 mm Hg vs. 41.8 mm Hg), and velocity reduction became more pronounced after CO2 normalization.

Conclusions:

  • Patients with severe SAS demonstrate reduced cerebral blood flow velocities.
  • Transcranial Doppler sonography is a potentially valuable noninvasive tool for evaluating cerebral hemodynamics in SAS.

Related Experiment Videos