Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional and dispositional tolerance develops during continuous cocaine exposure.

E K Johansson1, S M Tucker, H B Ginn

  • 1Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0613.

European Journal of Drug Metabolism and Pharmacokinetics
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Baseline characteristics of atopic eczema patients enrolled in seven European registries united in the TREatment of ATopic eczema (TREAT) registry taskforce.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

Childhood atopic dermatitis is associated with cardiovascular risk factors in young adulthood-A population-based cohort study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2023
Same author

Systemic treatment of children and adolescents with atopic dermatitis aged ≥2 years: a Delphi consensus project mapping expert opinion in Northern Europe.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Prevalence and characteristics of atopic dermatitis among young adult females and males-report from the Swedish population-based study BAMSE.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Psychiatric conditions in children with atopic dermatitis.

The British journal of dermatology·2021
Same author

Association between atopic dermatitis and autoimmune diseases: a population-based case-control study.

The British journal of dermatology·2020

Chronic high-dose cocaine administration in rats rapidly induced tolerance to its pressor effects but not heart rate increases. Some rats experienced cardiotoxicity, while behavioral stereotypy showed initial sensitization followed by tolerance.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Toxicology

Background:

  • Chronic high-dose cocaine abuse is prevalent, yet tolerance and sensitization mechanisms remain unclear.
  • Understanding these adaptations is crucial for addressing cocaine addiction and its health consequences.

Purpose of the Study:

  • To investigate the development of tolerance and sensitization to chronic high-dose cocaine administration in rats.
  • To monitor physiological and behavioral responses during continuous intravenous cocaine infusion.

Main Methods:

  • Male Sprague-Dawley rats received continuous intravenous infusions of cocaine hydrochloride (150 mg/kg/day) for 10 days.
  • Daily monitoring included body weight, food/water intake, excretion, blood pressure, heart rate, and stereotypic behavior.
  • Plasma cocaine and metabolite (BEG) levels were analyzed using gas chromatography/mass spectrometry.

Related Experiment Videos

Main Results:

  • Rapid tolerance developed to cocaine's hypertensive effects within 24 hours.
  • Tolerance did not develop to heart rate increases; some animals exhibited cardiotoxic bradycardia, leading to death.
  • Behavioral stereotypy initially sensitized then rapidly became tolerant by day 5.
  • No withdrawal signs were observed 24 hours post-cessation.
  • Plasma cocaine levels stabilized then declined after day 5.

Conclusions:

  • Chronic high-dose cocaine induces rapid tolerance to cardiovascular effects but not heart rate changes, with potential cardiotoxicity.
  • Sensitization followed by tolerance occurs for behavioral stereotypy.
  • The study highlights complex adaptive responses to sustained cocaine exposure.