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Updated: Sep 28, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
Blockade of hyperalgesia and neurogenic oedema by topical application of nitroglycerin
S H Ferreira1, B B Lorenzetti, L H Faccioli
1Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, São Paulo, Brazil.
Abstract:
Surprisingly, a single topical application of a nitroglycerin (NTG) gel in humans has been shown to cause analgesia and to reduce oedema in thrombophlebitis. In the present investigation, we showed that the NTG gel reduces prostaglandin E2-induced hyperalgesia and blocks neurogenic inflammation induced in rat skin by antidromic electrical stimulation of the saphenous nerve. These results offer an explanation for the effects of topical application of NTG observed in thrombophlebitis, which may be common to other cutaneous pathologies. The data also support the development of nitrates the effects of which are restricted to the site of application.
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