Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Catecholamine response to methamphetamine is related to glucocorticoid levels but not to pleasurable subjective response.

Pharmacopsychiatry·2006
Same author

Fear in children and adolescents: relations with negative life events, attributional style, and avoidant coping.

Journal of child psychology and psychiatry, and allied disciplines·2002
Same author

Allergic reactions after ingestion of erythritol-containing foods and beverages.

The Journal of allergy and clinical immunology·2001
Same author

Caveat emptor: editors beware.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2001
Same author

The psychological effects of Hurricane Andrew on ethnic minority and Caucasian children and adolescents: a case study.

Cultural diversity & ethnic minority psychology·2001
Same author

Cardiovascular effects of 3,4-methylenedioxymethamphetamine. A double-blind, placebo-controlled trial.

Annals of internal medicine·2000

Related Experiment Video

Updated: Jun 21, 2026

Phospho Flow Cytometry with Fluorescent Cell Barcoding for Single Cell Signaling Analysis and Biomarker Discovery
08:38

Phospho Flow Cytometry with Fluorescent Cell Barcoding for Single Cell Signaling Analysis and Biomarker Discovery

Published on: October 4, 2018

HEMOGLOBIN F TEXAS: GAMMA-CHAIN VARIANT.

R G SCHNEIDER, R T JONES

    Science (New York, N.Y.)
    |April 9, 1965
    PubMed
    Summary

    A novel abnormal fetal hemoglobin, Hemoglobin F(Texas), was identified in infants. This variant involves a specific amino acid substitution in the gamma-chain of hemoglobin.

    Area of Science:

    • Biochemistry
    • Genetics
    • Hematology

    Background:

    • Fetal hemoglobin (HbF) is crucial for oxygen transport in utero.
    • Variations in hemoglobin structure can lead to clinical implications.

    Purpose of the Study:

    • To characterize a newly discovered abnormal fetal hemoglobin variant.
    • To determine the structural basis of Hemoglobin F(Texas).

    Main Methods:

    • Analysis of cord blood samples.
    • Chemical structure studies of the abnormal hemoglobin.

    Main Results:

    • Identified an abnormal fetal hemoglobin, designated Hemoglobin F(Texas).
    • Found in multiple related infants and one unrelated infant.
    Keywords:
    CHROMATOGRAPHYELECTROPHORESISFETAL HEMOGLOBINGEL DIFFUSION TESTSHEMOGLOBINS, ABNORMALPEPTIDES

    More Related Videos

    Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
    07:49

    Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

    Published on: July 17, 2019

    Fluorescence Labeling to Visualize Low-Expressed Proteins in Zebrafish
    09:38

    Fluorescence Labeling to Visualize Low-Expressed Proteins in Zebrafish

    Published on: January 24, 2025

    Related Experiment Videos

    Last Updated: Jun 21, 2026

    Phospho Flow Cytometry with Fluorescent Cell Barcoding for Single Cell Signaling Analysis and Biomarker Discovery
    08:38

    Phospho Flow Cytometry with Fluorescent Cell Barcoding for Single Cell Signaling Analysis and Biomarker Discovery

    Published on: October 4, 2018

    Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
    07:49

    Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

    Published on: July 17, 2019

    Fluorescence Labeling to Visualize Low-Expressed Proteins in Zebrafish
    09:38

    Fluorescence Labeling to Visualize Low-Expressed Proteins in Zebrafish

    Published on: January 24, 2025

  • Structural analysis revealed a lysyl residue substitution for a glutamyl residue in the gamma-chain.

    • Conclusions:

    • Hemoglobin F(Texas) represents a novel structural variant of fetal hemoglobin.
    • The identified substitution provides insight into hemoglobinopathies.