Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Marked decrease of A10 dopamine neuronal firing during ethanol withdrawal syndrome in rats.

M Diana1, M Pistis, A Muntoni

  • 1B.B. Brodie Department of Neuroscience, University of Cagliari, Italy.

European Journal of Pharmacology
|October 20, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intraoperative technologies to assess margin status during radical prostatectomy - a narrative review.

Prostate cancer and prostatic diseases·2024
Same author

Consensus conference statement on fluorescence-guided surgery (FGS) ESSO course on fluorescence-guided surgery.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2023
Same author

European Association for Endoscopic Surgery (EAES) consensus on Indocyanine Green (ICG) fluorescence-guided surgery.

Surgical endoscopy·2023
Same author

Factor-based assessment of continuous bio-H<sub>2</sub> production from cheese whey.

Chemosphere·2022
Same author

Intraoperative imaging for remnant viability assessment in bilateral posterior retroperitoneoscopic partial adrenalectomy in an experimental model.

The British journal of surgery·2020
Same author

A novel method for near-infrared fluorescence imaging of the urethra during perineal and transanal surgery: demonstration in a cadaveric model.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2020
Same journal

Astaxanthin inhibits platelet-mediated thrombosis via suppression of bidirectional αIIbβ3 signaling.

European journal of pharmacology·2026
Same journal

Repurposing of alogliptin to mitigate experimentally-induced ulcerative colitis and its associated pulmonary injury in rats through regulating inflammatory, necroptotic, and ER stress pathways.

European journal of pharmacology·2026
Same journal

Erianin ameliorates liver fibrosis through the PRDX3/NLRX1 axis.

European journal of pharmacology·2026
Same journal

4-Octyl itaconate attenuates renal calculi formation by inhibiting ferroptosis and oxidative stress via the Nrf2-HO-1/SLC7A11 axis.

European journal of pharmacology·2026
Same journal

VER155008 rescues cognitive impairment in P301S tauopathy mice by promoting HSPA8-mediated lipophagy.

European journal of pharmacology·2026
Same journal

Okanin alleviates osteoarthritis by suppressing oxidative stress and pyroptosis via Nrf2/HO-1 activation.

European journal of pharmacology·2026
See all related articles

Ethanol dependence reduces mesoaccumbens dopaminergic neuron activity during withdrawal. This decreased neuronal firing in ethanol-dependent rats may explain the negative feelings associated with alcohol withdrawal syndrome.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Addiction Research

Background:

  • Ethanol withdrawal syndrome (EWS) is characterized by aversive symptoms.
  • The mesoaccumbens dopaminergic pathway plays a crucial role in reward and motivation.
  • Changes in dopaminergic activity are implicated in addiction and withdrawal.

Purpose of the Study:

  • To investigate the electrophysiological activity of mesoaccumbens dopaminergic neurons during ethanol withdrawal.
  • To compare neuronal activity between ethanol-dependent and control rats.

Main Methods:

  • Electrophysiological recordings were used to monitor spontaneous firing and spike patterns.
  • Experiments were conducted on ethanol-dependent and control rat models.

Related Experiment Videos

Main Results:

  • Ethanol-dependent rats exhibited approximately 50% reduction in spontaneous firing of mesoaccumbens dopaminergic neurons compared to controls.
  • The number of spikes per burst was also significantly reduced in ethanol-dependent rats during withdrawal.

Conclusions:

  • Reduced mesoaccumbens dopaminergic neuron activity during ethanol withdrawal is a key finding.
  • This hypodopaminergic state may underlie the aversive effects experienced during EWS.
  • Findings suggest a neurobiological basis for the negative affective states in alcohol withdrawal.