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Overview of cancer and aging: a mechanistic perspective
1National Center for Toxicological Research, Jefferson, Arkansas 72079.
Experimental Gerontology
|September 1, 1992
Abstract:
Cancer and aging are approached from the standpoint of damaging agents affecting target cell, local cellular environment, and the organism as a whole. The effects of exogenous agents are represented in a model emphasizing absorption, organismic disposition, and cellular disposition. Endogenous agents are represented similarly. The extent of endogenous damage is illustrated. Factors in the expression of damage as a toxic endpoint are emphasized, with the example of caloric restriction used as an example of environmental modulation of response.