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The effect of shock on blood oxidation-reduction potential
M Jellinek1, B Chandel, R Abdulla
1Department of Surgery, St. Louis University School of Medicine, Missouri 63104.
Experientia
|October 15, 1992
Summary
Hemorrhagic shock significantly drops blood redox potential, indicating impaired cellular respiration. Albumin infusion temporarily improved potential but did not fully restore function, suggesting a large reductive load persists after shock.
Area of Science:
- Physiology
- Biochemistry
- Medical Research
Background:
- Oxidation-reduction (redox) potential reflects cellular metabolic state.
- Hemorrhagic shock causes significant physiological derangement.
- Understanding redox changes is crucial for assessing shock recovery.
Purpose of the Study:
- To measure blood redox potential changes in rabbits during hemorrhagic shock.
- To evaluate the effect of albumin infusion on redox potential post-shock.
- To assess the restoration of cellular respiration after shock.
Main Methods:
- Blood samples were collected from rabbits undergoing induced hemorrhagic shock.
- Redox potential was measured in arterial and venous blood, corrected for pH.
- Albumin was infused as a mild oxidizing agent to assess its therapeutic effect.
Main Results:
- Control arterial and venous redox potentials were established (-8.8 mV and -18.0 mV, respectively).
- Hemorrhagic shock caused a significant drop in both arterial (13 mV) and venous (20 mV) redox potentials.
- Albumin infusion temporarily normalized venous redox potential, but it decreased upon discontinuation; full recovery was not achieved 2 hours post-reperfusion.
Conclusions:
- Hemorrhagic shock imposes a substantial reductive load, impairing cellular respiration.
- Reperfusion alone or with albumin did not fully reverse the shock-induced reductive state.
- Inadequate restoration of cellular respiration may hinder recovery and organ function post-shock.