Very late return of spermatogenesis after chlorambucil therapy: case reports

Two men were treated for a nephrotic syndrome with high-dose chlorambucil therapy; 6.5 and 14 years later, respectively, both were azoospermic with high plasmatic FSH values. Both patients showed active spermatogenesis, 15 and 19 years after the end of the treatment. This suggests that a return of spermatogenesis can occur even after very high cumulative doses of chlorambucil (between 3,000 and 6,500 mg) and after a very long time.