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Updated: Aug 24, 2026
Isolation of Neonatal Extrahepatic Cholangiocytes
Published on: June 5, 2014
[Intravenous cholangio-cystography during childhood (author's transl)]
Insights
Intravenous cholangio-cystography effectively visualizes the biliary tree and gallbladder in children. Both injection and infusion methods using Biligram demonstrated safety, with no observed allergic reactions or liver enzyme changes.
Area of Science:
- Pediatric Radiology
- Diagnostic Imaging
- Hepatobiliary System
Context:
- Intravenous cholangio-cystography is a diagnostic procedure.
- Assessing the biliary tree and gallbladder requires effective contrast agents and methods.
- Pediatric patients require specific considerations for contrast administration and dosage.
Purpose:
- To evaluate the efficacy and safety of intravenous cholangio-cystography in pediatric patients.
- To compare the diagnostic quality of contrast medium injection versus infusion for cholangio-cystography.
- To assess the impact of contrast media on liver function enzymes in children.
Summary:
- Twenty-five pediatric patients (aged 2-15 years) underwent intravenous cholangio-cystography using Biligram (17% infusion, 35% injection).
- Contrast dosage was age-dependent for both infusion and injection methods.
- Both methods provided good visualization of the biliary tree and gallbladder without allergic reactions or adverse effects on liver enzymes (total bilirubin, GOT, GPT, GLDH, alkaline phosphatase).
Impact:
- Establishes intravenous cholangio-cystography as a safe and effective imaging modality for pediatric hepatobiliary evaluation.
- Provides evidence-based contrast dosage guidelines for pediatric cholangio-cystography.
- Supports the use of Biligram in pediatric radiology for visualizing the biliary system.
Abstract:
Twenty-five intravenous cholangio-cystograms were carried out in children aged 2 to 15 years (10 by injection, 15 by infusion). Total bilirubin, GOT, GPT, GLDH and alkaline phosphatase were determined before and after injection of the contrast medium. The contrast media used were "Biligram for infusion" (17%) and "biligram for injection" (35%). Contrast dose per kilo body weight depends on the age of the patient: a) For infusion: infants 1.6 ml/kg/KG, small children 1.2 ml/kgKG, older children 0.8 ml/kg/KG. b) for injection: infants 0.8 ml/kg/KG, small children 0.6 ml/kg/KG, older children 0.4 ml/kg/KG. Both methods, in the above doses, provided good demonstration of the biliary tree and gall bladder. Films were taken at 30 minutes, 60 minutes and 90 minutes after the end of the injection, and 40 minutes after a fatty meal. No allergic reactions were observed, nor any effect on the liver enzymes.
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