[The pathomorphological changes in the internal organs in experimental chronic red phosphorus poisoning]

Area of Science:

• Toxicology
• Pathology
• Animal Studies

Background:

• Red phosphorus is a toxic substance with potential health implications.
• Understanding the chronic effects of red phosphorus exposure is crucial for risk assessment.

Purpose of the Study:

• To investigate the pathomorphologic changes induced by chronic red phosphorus poisoning in rats.
• To identify the temporal progression of toxic effects across different organs.

Main Methods:

• Experiments were conducted on 76 rats of both sexes.
• Rats were exposed to red phosphorus for varying chronic durations (15 days to 4 months).
• Morphologic and pathomorphologic examinations of viscera and brain were performed.

Main Results:

• Chronic red phosphorus poisoning led to dystrophic changes and hyperemia.
• The liver, stomach, and small intestine showed the earliest pathomorphologic alterations.
• As intoxication prolonged, changes extended to other internal organs and the brain.

Conclusions:

• Red phosphorus induces dose- and time-dependent pathomorphologic changes in rats.
• Early detection of changes in the liver, stomach, and intestines is indicative of red phosphorus toxicity.
• The study highlights the systemic impact of chronic red phosphorus exposure.