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Pyoderma gangrenosum: associations revisited.

C B Ko1, S Walton, E H Wyatt

  • 1Department of Dermatology, Hull Royal Infirmary, Leeds, United Kingdom.

International Journal of Dermatology
|August 1, 1992
PubMed
Summary
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Pyoderma gangrenosum (PG) is a rare inflammatory skin disease. This study found PG frequently co-occurred with rheumatoid arthritis and showed a female predominance.

Area of Science:

  • Dermatology
  • Rheumatology
  • Internal Medicine

Background:

  • Pyoderma gangrenosum (PG) is a rare, ulcerative neutrophilic dermatosis.
  • Its etiology is often idiopathic, but associations with systemic diseases are recognized.

Purpose of the Study:

  • To investigate the clinical presentation and associated conditions in patients with pyoderma gangrenosum.
  • To identify patterns and comorbidities in a cohort over a 24-year period.

Main Methods:

  • Retrospective case series analysis.
  • Review of 14 patients diagnosed with pyoderma gangrenosum at Hull Royal Infirmary Dermatology Department over 24 years.

Main Results:

  • Seven of 14 cases (50%) were associated with rheumatoid arthritis (RA), with 5 sero-positive RA cases.

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  • One case each was linked to ulcerative colitis and psoriasis, polycythemia rubra vera, and syphilis.
  • A female preponderance was observed (10 women: 4 men).
  • Age at presentation ranged from 30 to 80 years.

    • Conclusions:

    • Pyoderma gangrenosum frequently presents with associated systemic conditions, notably rheumatoid arthritis.
    • The findings support a significant female predilection for pyoderma gangrenosum.
    • Further research into the underlying mechanisms connecting PG and its comorbidities is warranted.