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Related Experiment Videos

Injectable microspheres with controlled drug release for glaucoma filtering surgery.

H Kimura1, Y Ogura, T Moritera

  • 1Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.

Investigative Ophthalmology & Visual Science
|November 1, 1992
PubMed
Summary

Biodegradable microspheres releasing adriamycin (ADR) effectively reduced post-surgical fibrosis and maintained filtering bleb patency in glaucoma surgery models. Lower ADR doses showed fewer corneal complications, suggesting a promising approach for preventing ocular fibrosis.

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Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Pharmacology

Background:

  • Post-surgical fibrosis is a common complication after glaucoma filtering surgery, potentially leading to bleb failure.
  • Controlled drug delivery systems aim to improve therapeutic outcomes and minimize side effects.

Purpose of the Study:

  • To evaluate the efficacy of biodegradable poly(lactic acid) microspheres for controlled release of adriamycin (ADR) in preventing post-surgical fibrosis.
  • To assess the impact of ADR-loaded microspheres on intraocular pressure and filtering bleb patency.

Main Methods:

  • A rabbit model of glaucoma filtering surgery (posterior lip sclerotomy) was used.
  • Subconjunctival injections of adriamycin (ADR)-loaded microspheres (100 or 200 micrograms) or control microspheres were administered immediately post-surgery.

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  • Intraocular pressure, filtering bleb patency, and corneal complications were monitored.

    • Main Results:

    • ADR-loaded microspheres significantly reduced intraocular pressure and prolonged filtering bleb patency compared to controls.
    • The 100 microgram ADR dose showed no corneal complications, while the 200 microgram dose caused transient peripheral corneal opacities and epithelial erosion.
    • Corneal issues resolved within 4 weeks in the higher dose group.

    Conclusions:

    • Controlled release of adriamycin via biodegradable microspheres is a promising strategy for preventing fibrosis after glaucoma surgery.
    • Optimizing ADR dosage is crucial to balance antifibrotic efficacy with ocular surface safety.