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Polypropylene small-diameter vascular grafts.

H P Greisler1, C W Tattersall, S C Henderson

  • 1Loyola University Medical Center, Maywood, Illinois 60153.

Journal of Biomedical Materials Research
|October 1, 1992
PubMed
Summary
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Polypropylene grafts show promising results as arterial substitutes, demonstrating high patency rates and excellent endothelialization. Further research into polypropylene vascular grafts is warranted for clinical applications.

Area of Science:

  • Biomaterials Science
  • Vascular Surgery
  • Polymer Engineering

Background:

  • Polypropylene's physical properties suggest its potential for use in vascular prostheses.
  • Existing arterial substitutes like Dacron and ePTFE have limitations.

Purpose of the Study:

  • To evaluate the efficacy of polypropylene grafts as arterial substitutes.
  • To compare the performance of polypropylene grafts against Dacron and ePTFE grafts in vivo.

Main Methods:

  • Polypropylene grafts were fabricated and implanted into the aortoiliac position in dogs.
  • Graft patency, thrombus formation, and histological characteristics were assessed over 16 months.
  • Control grafts included Dacron and expanded polytetrafluoroethylene (ePTFE).

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Main Results:

  • Late patency rates were 81% for polypropylene, 69% for Dacron, and 20% for ePTFE.
  • Polypropylene grafts achieved confluent endothelialization by 1 month post-implantation.
  • Histological analysis revealed myofibroblast and macrophage infiltration, forming inner capsules similar to Dacron grafts.

Conclusions:

  • Polypropylene grafts demonstrate superior late patency compared to ePTFE grafts.
  • The observed endothelialization and tissue response suggest potential clinical efficacy for polypropylene in arterial reconstruction.