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TREATMENT OF INFECTIONS WITH COLISTIMETHATE SODIUM (COLY-MYCIN)

K C RODGER, M NIXON, H O TONNING

    Canadian Medical Association Journal
    |July 24, 1965
    PubMed

    Insights

    Colistimethate sodium effectively treated Gram-negative infections, particularly Pseudomonas. While some patients relapsed, it shows promise for urinary and respiratory infections, excluding Proteus.

    Area of Science:

    • Pharmacology
    • Infectious Diseases
    • Clinical Medicine

    Background:

    • Gram-negative bacterial infections pose significant treatment challenges.
    • Colistimethate sodium is an antibiotic used for serious infections.
    • Complicated infections often involve foreign bodies, impacting treatment outcomes.

    Purpose of the Study:

    • To evaluate the efficacy and safety of colistimethate sodium in treating Gram-negative infections.
    • To assess treatment outcomes in patients with complicated urinary tract and respiratory tract infections.
    • To identify specific bacterial species and clinical scenarios where colistimethate sodium is most effective.

    Main Methods:

    • A clinical study involving 17 patients treated with colistimethate sodium.
    • Dosage ranged from 1.1-2.3 mg/lb/day, with a maximum of 2.4 g over eight days.
    • Infections caused by Pseudomonas, Aerobacter, and E. coli were targeted, with some cases complicated by foreign bodies.

    Main Results:

    • Six patients achieved bacteriological cure, while eight relapsed.
    • Three patients experienced a replacement of the infecting organism.
    • The best responses were observed in patients with Pseudomonas infections.
    • Common side effects included nausea, vomiting, vertigo, paresthesias, and injection site pain.

    Conclusions:

    • Colistimethate sodium is a viable treatment option for Gram-negative infections, especially those caused by Pseudomonas.
    • The antibiotic demonstrated utility in treating both urinary tract and respiratory tract infections.
    • Exclusion of Proteus organisms from treatment efficacy is noted.
    • Further research may be warranted for optimizing colistimethate sodium use in complex cases.
    Keywords:
    AEROBACTERCOLISTINDRUG THERAPYESCHERICHIA COLI INFECTIONSGERIATRICSPSEUDOMONAS INFECTIONSRESPIRATORY TRACT INFECTIONSTOXICOLOGIC REPORTURINARY TRACT INFECTIONS

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