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The role of the effective concentration in interpreting hemolysis data
1Department of Pharmaceutical Sciences, College of Pharmacy, University of Arizona, Tucson.
Journal of Parenteral Science and Technology : a Publication of the Parenteral Drug Association
|September 1, 1992
Abstract:
Problems inherent in traditional methods of determining the hemolytic activity of parenteral compounds are discussed. Data taken from a study which closely models the conditions present for an intravenous injection are re-examined. An equation is given which combines several variables into a single parameter, the effective concentration. A strong relationship is found between the effective concentration of the compound of interest and the hemolysis produced.