Related Experiment Videos
[Function, molecular structure and gene expression regulation of interleukin 9 (IL-9)]
1Department of Hygiene, Kyoto Prefectural University of Medicine.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 1, 1992
Summary
Interleukin-9 (IL-9)/P40, a murine growth factor, supports helper T-cell proliferation and mast cell growth. Human IL-9, similar to murine P40, also influences erythroid burst formation.
Area of Science:
- Immunology
- Hematology
Context:
- Interleukin-9 (IL-9)/P40 is a murine growth factor identified in ConA stimulated CD4+ T-cells.
- Murine IL-9/P40 supports proliferation of mucosal mast cells and indirectly induces erythroid burst formation.
Purpose:
- To identify, clone cDNA, and characterize the biological activities of murine and human Interleukin-9 (IL-9)/P40.
- To compare the functions of murine and human IL-9.
Summary:
- Murine Interleukin-9 (IL-9)/P40, a growth factor for helper T-cell clones, is produced by stimulated T-cells.
- Human IL-9, a homologue to murine P40, was cloned and shows sequence similarity.
- Human IL-9 supports erythroid burst formation responsive to IL-3.
Impact:
- Provides insights into the biological roles of IL-9 in both murine and human systems.
- Highlights the conserved functions of IL-9 in hematopoiesis and immune cell regulation.
- Facilitates further research into IL-9's therapeutic potential in related conditions.