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Related Experiment Videos

[Acid-base regulation: a general introduction].

Y Honda1

  • 1Department of Physiology, School of Medicine, Chiba University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 1, 1992
PubMed
Summary

The body maintains a relative constant alkalinity, with intracellular pH (pHi) matching this neutral pH (pN). This balance is crucial for cellular function and metabolic processes, even at lower temperatures.

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Area of Science:

  • Physiology
  • Biochemistry

Context:

  • Body fluid acid-base homeostasis is maintained at a relative constant alkalinity (pN), slightly higher than neutral pH.
  • Intracellular pH (pHi) is regulated to approximate pN, creating a pH gradient with extracellular fluid (pHo).

Purpose:

  • To explain the concept of relative constant alkalinity in physiological systems.
  • To highlight the significance of maintaining intracellular pH for cellular functions.

Summary:

  • Acid-base balance in animals is achieved through relative constant alkalinity (pN), with intracellular pH (pHi) matching pN.
  • Temperature influences pN, affecting normal blood pH in cold-blooded animals and humans at lower temperatures.
  • Maintaining pHi at pN ensures cellular integrity by retaining ionized molecules and facilitating metabolic processes.

Impact:

  • Provides insight into the fundamental mechanisms of cellular pH regulation.
  • Explains the physiological basis for pH variations in different thermal conditions.
  • Underscores the importance of pH homeostasis for overall metabolic efficiency and cellular function.

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