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[Reversible mydriasis and cycloplegia after isocyanate exposure]
1Universitätsaugenklinik, Bonn.
Klinische Monatsblatter Fur Augenheilkunde
|August 1, 1992
Summary
Polyurethane production workers experienced temporary vision problems like dilated pupils (mydriasis) and blurred vision (cycloplegia). These symptoms resolved after stopping work, suggesting isocyanate exposure as the likely cause.
Area of Science:
- Occupational Health
- Toxicology
- Ophthalmology
Background:
- Polyurethane production involves complex chemical reactions.
- Exposure to chemical intermediates can pose occupational health risks.
Observation:
- Three polyurethane production workers presented with unexplained mydriasis and cycloplegia.
- One patient also exhibited transient corneal stroma opacification.
Findings:
- Symptoms resolved within 3-5 days after cessation of work.
- Strong evidence suggests intoxication with the aryl moiety of isocyanate molecules.
Implications:
- Highlights the potential ocular toxicity of isocyanates in occupational settings.
- Underscores the need for monitoring and protective measures for workers in polyurethane manufacturing.
- Suggests isocyanates as a potential cause of toxic mydriasis and cycloplegia.