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Filtering seton implant for glaucoma: initial animal trial.
H D Hoskins1, M V Drake, D S Minckler
1Department of Ophthalmology, University of California, San Francisco 94143.
Ophthalmic Surgery
|October 1, 1992
Summary
A new silicone filtering seton effectively lowered intraocular pressure (IOP) in rhesus monkeys after laser therapy. This glaucoma device showed sustained IOP reduction over 24 months with minimal inflammation.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Veterinary Medicine
Background:
- Elevated intraocular pressure (IOP) is a primary risk factor for glaucoma.
- Argon-laser trabeculoplasty is a common procedure to reduce IOP, but may require adjunctive therapies.
- Developing novel surgical devices for IOP management is crucial.
Purpose of the Study:
- To evaluate the efficacy and safety of a newly developed silicone filtering seton device.
- To assess the long-term intraocular pressure (IOP) lowering effect of the seton in a primate model.
- To determine the inflammatory response post-implantation.
Main Methods:
- A silicone filtering seton was implanted in five eyes of four rhesus monkeys following argon-laser trabeculoplasty.
- Intraocular pressure (IOP) was monitored pre- and post-implantation.
- One animal was euthanized at 6 weeks; the remaining three were observed for 17-24 months.
Main Results:
- Postoperative inflammation was mild to moderate and resolved within the first week.
- The silicone seton device reduced IOP by 18% to 70% compared to pre-implantation levels.
- In unilaterally operated eyes, final IOP was equal to or lower than the fellow eye; in the bilaterally operated animal, both eyes showed reduced IOP.
Conclusions:
- The novel silicone filtering seton is a safe and effective device for lowering intraocular pressure (IOP).
- The device demonstrates sustained IOP reduction over an extended follow-up period.
- This implantable device shows promise as an adjunctive therapy for managing elevated IOP.