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Familial ogee roots, tooth mobility, oligodontia, and microdontia
1Christchurch Hospital, New Zealand.
Oral Surgery, Oral Medicine, and Oral Pathology
|November 1, 1992
Summary
A new term, ogee, describes dome-shaped incisor roots found in a family study. This dental anomaly, linked to microdontia and oligodontia, follows an autosomal dominant inheritance pattern.
Area of Science:
- Dentistry
- Human Genetics
- Developmental Biology
Background:
- Dental anomalies present a significant challenge in clinical practice and genetic research.
- Understanding the genetic basis of tooth development is crucial for diagnosing and managing inherited dental conditions.
Observation:
- A family study identified a distinct dental abnormality characterized by dome or onion-shaped incisor roots, termed 'ogee'.
- The condition was observed in association with microdontia, oligodontia, and tooth mobility in permanent upper incisors.
Findings:
- Genetic analysis of 47 family members revealed that the ogee incisor trait is inherited in an autosomal dominant pattern.
- This suggests a single gene mutation is responsible for the observed dental abnormalities.
Implications:
- The identification of the 'ogee' trait provides a new descriptor for a specific dental anomaly.
- Understanding its autosomal dominant inheritance aids in genetic counseling and predicting risk within affected families.
- Further research can elucidate the specific gene and molecular mechanisms underlying ogee incisor formation.