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Some aspects of ocular function after precurarization.

S Eriksen, T Bramsen, P Hommelgaard

    Acta Anaesthesiologica Scandinavica
    |January 1, 1977
    PubMed
    Summary
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    Nondepolarizing muscle relaxants, like D-tubocurarine, can reduce intraocular pressure and affect vision by impacting eye muscle accommodation. These effects are dose-dependent and may influence pre-anesthetic medication choices.

    Area of Science:

    • Ophthalmology
    • Anesthesiology
    • Pharmacology

    Background:

    • Nondepolarizing muscle relaxants are sometimes used before succinylcholine to mitigate side effects.
    • The impact of these relaxants on ocular parameters like intraocular pressure and accommodation requires further investigation.

    Purpose of the Study:

    • To investigate the effects of D-tubocurarine, pancuronium, and gallamine on intraocular pressure and monocular accommodation in healthy volunteers.
    • To understand the potential mechanisms behind these ocular changes.

    Main Methods:

    • Administration of varying doses of D-tubocurarine, pancuronium, and gallamine to unmedicated volunteers.
    • Measurement of monocular near point of accommodation, grip strength, and intraocular pressure before and after drug administration.

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    Main Results:

    • D-tubocurarine caused a dose-dependent recession in the near point of accommodation and exophoria.
    • D-tubocurarine and pancuronium significantly reduced intraocular pressure for approximately 7 minutes.
    • Gallamine also decreased intraocular pressure, but to a lesser extent and with delayed statistical significance.

    Conclusions:

    • Nondepolarizing muscle relaxants can induce significant changes in ocular parameters, including reduced intraocular pressure and altered accommodation.
    • These effects may be related to the relaxation of extraocular muscles, leading to a more spherical eyeball shape.
    • Findings suggest a potential role for these agents in managing intraocular pressure and visual function during anesthesia.