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Pharmacokinetics of carprofen administered intravenously to sheep
E M Welsh1, P Baxter, A M Nolan
1Department of Veterinary Pharmacology, University of Glasgow Veterinary School, Bearsden.
Research in Veterinary Science
|September 1, 1992
Abstract:
Carprofen was administered intravenously to sheep at two dose rates (0.7 and 4.0 mg kg-1), and the pharmacokinetics of the drug studied. Plasma concentrations of the drug were measured by high performance liquid chromatography. Carprofen had a small volume of distribution (Vd[area], 95.5 and 118.4 ml kg-1), a prolonged elimination half-life (t1/2 beta, 26.1 and 33.7 hours) and a slow body clearance rate (Clb, 2.5 ml kg-1 h-1) in sheep.