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Clinical experience with OM-85 BV in upper and lower respiratory tract infections
1Service de Pneumologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Abstract:
The preventive effect of OM-85 BV on recurrent ENT and respiratory tract infections has been documented in a series of clinical trials. This article reviews the more significant controlled clinical trials investigating the efficacy and safety of OM-85 BV in airway infections. The literature reviewed covers all age groups. In summary, the administration of OM-85 BV was associated with a decrease in the number of acute exacerbations, with an increase in the number of patients remaining free from infections and with a decrease in antibiotic consumption. These results indicate the efficacy of oral immunostimulation with the bacterial extract OM-85 BV in all age groups and demonstrate its protective effect against recurrent airway infections.
Insights
OM-85 BV, an oral immunostimulant, effectively prevents recurrent ear, nose, throat (ENT), and respiratory infections across all age groups. It reduces infection severity, increases infection-free periods, and lowers antibiotic use.
Area of Science:
- Immunology
- Infectious Diseases
- Pharmacology
Background:
- Recurrent respiratory and ENT infections pose a significant health burden.
- Bacterial extracts are explored for their immunomodulatory properties.
- OM-85 BV is a widely used bacterial lysate for immune stimulation.
Purpose of the Study:
- To review controlled clinical trials on OM-85 BV efficacy and safety.
- To evaluate OM-85 BV's preventive effects in airway infections.
- To assess OM-85 BV's impact across all age groups.
Main Methods:
- Systematic review of controlled clinical trials.
- Analysis of studies investigating OM-85 BV in airway infections.
- Inclusion of trials covering pediatric and adult populations.
Main Results:
- OM-85 BV administration correlated with fewer acute exacerbations.
- Increased proportion of patients remained infection-free.
- Reduced antibiotic consumption was observed in OM-85 BV treated groups.
Conclusions:
- Oral immunostimulation with OM-85 BV is effective in preventing recurrent airway infections.
- OM-85 BV demonstrates protective benefits across all age demographics.
- The bacterial extract OM-85 BV offers a viable strategy for managing recurrent infections.