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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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[Current aspects of analgetics-induced asthma]
1Luzerner Höhenklinik, Montana.
Schweizerische Rundschau Fur Medizin Praxis = Revue Suisse De Medecine Praxis
|November 3, 1992
Summary
Aspirin intolerance affects up to 10% of asthmatics, causing bronchospasm. Avoid NSAIDs; paracetamol is a safer alternative for managing aspirin-induced asthma.
Area of Science:
- Pharmacology
- Immunology
- Pulmonology
Context:
- Aspirin intolerance affects up to 10% of asthma patients.
- A common triad includes aspirin intolerance, glucocorticoid-dependent asthma, and nasal polyps.
- Reactions to aspirin are not mediated by immunoglobulin E (IgE).
Purpose:
- To summarize the clinical presentation and management of aspirin intolerance in asthmatics.
- To highlight cross-intolerance with other non-steroidal anti-inflammatory drugs (NSAIDs).
- To discuss alternative medications and desensitization therapies.
Summary:
- Patients with aspirin intolerance experience bronchospasm upon aspirin ingestion.
- Cross-intolerance is prevalent with cyclooxygenase-inhibiting NSAIDs, necessitating their avoidance.
- Paracetamol is generally a safe alternative, while acetylsalicylic acid desensitization is rarely indicated.
Impact:
- Provides guidance for clinicians managing asthma patients with suspected aspirin intolerance.
- Emphasizes the importance of avoiding specific NSAIDs to prevent adverse respiratory events.
- Informs patients about safe alternative medications and potential desensitization treatments.
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