Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hypoglycemia and multiple myeloma].

C Merlo1, C Wimpfheimer, J Muser

  • 1Medizinische Klinik, Kantonsspital Luzern.

Schweizerische Medizinische Wochenschrift
|October 24, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decreased mRNA and protein stability of W1282X limits response to modulator therapy.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2019
Same author

Frequency comb offset detection using supercontinuum generation in silicon nitride waveguides.

Optics express·2015
Same author

Semi-classical approach to compute RABBITT traces in multi-dimensional complex field distributions.

Optics express·2015
Same author

Safety and efficacy of Temsirolimus in combination with Bendamustine and Rituximab in relapsed mantle cell and follicular lymphoma.

Leukemia·2015
Same author

Impact of prior treatment on outcome of transformed follicular lymphoma and relapsed de novo diffuse large B cell lymphoma: a retrospective multicentre analysis.

Annals of hematology·2015
Same author

Breakdown of the dipole approximation in strong-field ionization.

Physical review letters·2014

A 78-year-old patient experienced severe hypoglycemia due to insulin autoimmune syndrome. Monoclonal antibodies produced by multiple myeloma caused the condition, successfully treated with plasmapheresis, octreotide, and chemotherapy.

Area of Science:

  • Endocrinology
  • Oncology
  • Immunology

Background:

  • Insulin autoimmune syndrome (IAS) is a rare disorder characterized by hypoglycemia.
  • It is often associated with autoantibodies against insulin and proinsulin.

Observation:

  • A 78-year-old patient presented with recurrent severe fasting and postprandial hypoglycemia.
  • Elevated plasma insulin and proinsulin antibodies were detected.
  • Investigations revealed a kappa-light chain multiple myeloma.

Findings:

  • Monoclonal IgG2 antibodies, identical to the paraprotein, were identified as the cause of insulin binding.
  • This confirmed the myeloma as the source of the autoantibodies in IAS.
  • Plasmapheresis, octreotide, and chemotherapy led to successful management.

Related Experiment Videos

Implications:

  • This case highlights a unique presentation of IAS linked to multiple myeloma.
  • It underscores the importance of investigating underlying malignancies in autoimmune disorders.
  • Effective management strategies involve addressing both the autoimmune phenomenon and the primary malignancy.