Clinical and hematological heterogeneity of T-cell derived lymphoproliferative diseases

Human lymphoproliferative disorders characterized by T derived neoplastic cells include Sezary's syndrome and mycosis fungoides, most childhood lymphoblastic lymphomas, about a quarter of acute lymphoblastic leukemias and rare cases of poorly differentiated immunoblastic or lymphocytic lymphomas as well as a small percentage of chronic lymphocytic leukemias. Particular emphasis is placed on the immunological diagnosis of T derived cells using various membrane markers and on the hematological and clinical features of each of the disorders discussed.