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Cardiac size and function in acromegaly.

J B Martins, R E Kerber, B M Sherman

    Circulation
    |November 1, 1977
    PubMed
    Summary
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    Acromegaly patients may develop heart problems like left ventricular hypertrophy, especially with long-term disease or high growth hormone levels. These cardiac changes may be reversible with treatment, indicating a specific acromegalic cardiomyopathy.

    Area of Science:

    • Cardiology
    • Endocrinology
    • Internal Medicine

    Background:

    • Acromegaly, a condition caused by excess growth hormone, is associated with cardiovascular complications.
    • Understanding the specific cardiac manifestations and their relationship to disease severity is crucial.

    Purpose of the Study:

    • To investigate cardiac abnormalities in acromegalic patients.
    • To identify factors associated with cardiac dysfunction, such as disease duration and growth hormone levels.

    Main Methods:

    • Utilized echocardiography, phonocardiography, stress electrocardiography with Thallium perfusion scanning, and gated radioisotope left ventricular angiocardiograms.
    • Evaluated sixteen patients with acromegaly, assessing cardiac structure and function.

    Main Results:

    Related Experiment Videos

    • Six patients with coexistent hypertension or coronary disease showed abnormalities including increased left ventricular mass index and impaired ventricular function.
    • Three patients with prolonged acromegaly (>13 years) or very high growth hormone (>100 ng/ml) exhibited concentric left ventricular hypertrophy, with one also showing dysfunction.
    • No cardiac abnormalities were observed in patients with shorter disease duration, lower growth hormone levels, or normalized levels after therapy.

    Conclusions:

    • Acromegaly is linked to a high prevalence of coronary artery and hypertensive heart disease.
    • A distinct, potentially reversible cardiomyopathy may occur in acromegaly, possibly due to prolonged disease or elevated growth hormone levels.