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Updated: Aug 7, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Secular trends in stroke incidence and mortality. The Framingham Study
P A Wolf1, R B D'Agostino, M A O'Neal
1Department of Neurology, Boston University School of Medicine, MA.
Stroke severity significantly decreased over three decades, but overall stroke incidence did not decline. Declining case fatality rates in men were mainly due to more isolated transient ischemic attacks.
Area of Science:
- Neurology
- Epidemiology
- Public Health
Background:
- US stroke mortality reduction previously linked to declining incidence.
- Emerging evidence suggests a trend of decreasing stroke severity.
Purpose of the Study:
- To examine secular trends in stroke incidence, prevalence, and fatality.
- Investigate changes in stroke severity over three decades.
Main Methods:
- Analysis of Framingham Study participants aged 55-64.
- Data collected across three decades: 1953, 1963, and 1973.
Main Results:
- No significant decline in overall stroke or transient ischemic attack (TIA) incidence/prevalence.
- Stroke severity significantly decreased over time; severe neurological deficits declined.
- Increased proportion of isolated TIAs led to apparent case-fatality decline in men.
Conclusions:
- Stroke incidence and fatality trends lacked a clear decline pattern.
- Stroke severity significantly decreased, but infarction incidence only fell in women.
- Declining case fatality in men primarily due to increased isolated TIAs, not reduced stroke severity.
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