Priming and cross-priming for H-Y in female mice

Although female mice (H-2b and H-2g) that are responders to H-Y are able to cross-prime for this antigen, their ability to do so varies from strain to strain and can be influenced by whether they are exposed to H-Y via a subcutaneous hind footpad inoculation of male cells or via a male skin graft. On the other hand, females (H-2k) that are low responders to H-Y only can be sensitized to male skin isografts following a hind footpad inoculation of syngeneic male cells.