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Related Experiment Videos

Hypersensitivity to trimethoprim.

M D Alonso1, C Marcos, I Davila

  • 1Department of Allergy, Hospital Ramón y Cajal, Madrid, Spain.

Allergy
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

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Severe allergic reactions to trimethoprim (TMP) were identified in three patients. Skin prick tests with TMP were positive, confirming TMP hypersensitivity and aiding diagnosis.

Area of Science:

  • Clinical Immunology
  • Allergy and Immunology
  • Pharmacology

Background:

  • Adverse drug reactions to antibiotics are a significant clinical concern.
  • Trimethoprim/sulfamethoxazole (TMP/SMX) is a commonly prescribed antibiotic combination.
  • Immediate hypersensitivity reactions necessitate accurate diagnostic methods.

Observation:

  • Three patients presented with severe immediate reactions or generalized urticaria after oral TMP/SMX.
  • Skin prick tests (SPT) were positive for TMP but negative for SMX in all affected patients.
  • Radioallergosorbent tests (RAST) for TMP-specific IgE antibodies were not significantly elevated.

Findings:

  • SPT with TMP proved effective in diagnosing TMP hypersensitivity.
  • Single-blind, placebo-controlled oral challenges confirmed TMP as the causative agent.

Related Experiment Videos

  • These findings indicate Type I hypersensitivity reactions specifically to TMP.

    • Implications:

    • Skin prick testing with trimethoprim is a valuable tool for diagnosing TMP hypersensitivity.
    • Distinguishing hypersensitivity to TMP versus SMX is crucial for patient management.
    • This study highlights the importance of targeted allergy testing for antibiotic adverse reactions.