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Related Experiment Videos

Control of cell density and pattern by intercellular signaling in Myxococcus development.

S K Kim1, D Kaiser, A Kuspa

  • 1Department of Biochemistry, Stanford University School of Medicine, California 94305.

Annual Review of Microbiology
|January 1, 1992
PubMed
Summary

Myxococcus xanthus bacteria use intercellular signals to coordinate development. Cell density regulates signaling efficiency, ensuring proper multicellular development and fruiting body formation.

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Area of Science:

  • Microbiology
  • Developmental Biology
  • Cellular Communication

Background:

  • Myxococcus xanthus exhibits complex multicellular behaviors including cooperative feeding, movement, and development.
  • These behaviors are coordinated through the transmission of intercellular signals.
  • Starvation triggers a developmental cascade leading to the formation of resilient, spore-filled fruiting bodies.

Purpose of the Study:

  • To review how Myxococcus xanthus utilizes extracellular signals for developmental coordination.
  • To examine the role of cell density in regulating intercellular signaling during development.
  • To understand how signaling ensures appropriate cell density for successful fruiting body formation.

Main Methods:

  • Genetic studies

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  • Biochemical analyses
  • Cell mosaic experiments

    • Main Results:

    • Intercellular signals are crucial for coordinating multicellular behavior in M. xanthus.
    • Cell density influences the efficiency of both early and late developmental signals.
    • Effective signaling is essential for maintaining proper cell density throughout development.

    Conclusions:

    • Myxococcus xanthus employs a sophisticated signaling system to regulate its multicellular development.
    • Cell density acts as a critical checkpoint, modulated by extracellular signals.
    • This density-dependent signaling ensures the successful progression of development and spore formation.