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Positive regulation in the gram-positive bacterium: Bacillus subtilis
A Klier1, T Msadek, G Rapoport
1Unité de Biochimie Microbienne, Centre National de la Recherche Scientifique, URA 1300, Paris, France.
Annual Review of Microbiology
|January 1, 1992
Summary
Gene expression in Bacillus subtilis is regulated by positive regulators that control transcription initiation. This review details various types of positive regulators, including antiterminators and two-component systems.
Area of Science:
- Microbiology
- Molecular Biology
- Genetics
Background:
- Prokaryotic gene expression is primarily regulated at transcription initiation.
- Two main regulatory modes exist: repressor binding and positive regulator interaction.
- Positive regulators activate transcription initiation through diverse mechanisms.
Purpose of the Study:
- To review and categorize the different types of positive regulators in Bacillus subtilis.
- To elucidate the mechanisms of action for various positive regulatory elements.
Main Methods:
- Literature review of transcriptional regulation in Bacillus subtilis.
- Classification of positive regulators based on their functional mechanisms.
- Identification of specific examples within Bacillus subtilis.
Main Results:
- Identified several classes of positive regulators in Bacillus subtilis.
- These include accessory regulatory polypeptides, classical positive regulators, ambiactive regulators, antiterminators, two-component signal transduction systems, and regulators associated with secondary sigma factors.
- Each class exhibits distinct mechanisms for promoting transcription initiation.
Conclusions:
- Bacillus subtilis employs a diverse array of positive regulators to control gene expression.
- Understanding these regulators is crucial for comprehending prokaryotic transcriptional control.
- The identified regulatory strategies highlight the complexity of gene expression in gram-positive bacteria.