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Epidermal growth factor receptor expression in Barrett's esophagus
D N Poller1, R J Steele, K Morrell
1Department of Histopathology, Queen's Medical Centre, Nottingham, England.
Archives of Pathology & Laboratory Medicine
|November 1, 1992
Summary
Epidermal growth factor receptor is expressed in Barrett
Area of Science:
- Gastroenterology and Oncology
- Molecular Biology
Background:
- Barrett's esophagus is a known complication of chronic gastroesophageal reflux disease.
- Intestinal metaplasia is the most common form of Barrett's change.
- Epidermal growth factor receptor (EGFR) is implicated in various cancers.
Purpose of the Study:
- To investigate the expression of epidermal growth factor receptor (EGFR) in intestinal metaplastic Barrett's epithelium.
- To explore the potential role of EGFR in the neoplastic transformation of Barrett's esophagus.
Main Methods:
- Immunohistochemical analysis was performed on six cases of known Barrett's esophagus.
- Detection of epidermal growth factor receptor (EGFR) expression within the Barrett's epithelium.
Main Results:
- All six examined cases demonstrated expression of epidermal growth factor receptor (EGFR).
- EGFR expression was localized to the intestinal metaplastic Barrett's epithelium.
Conclusions:
- Epidermal growth factor receptor (EGFR) expression is present in intestinal metaplastic Barrett's epithelium.
- EGFR may play a role in the neoplastic progression of Barrett's esophagus, potentially via autocrine signaling.
- Further research is needed to clarify the clinical significance of EGFR in Barrett's esophagus and its association with neoplastic transformation.