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Cefotetan-induced immune hemolytic anemia.

C E Chenoweth¹, W J Judd, E A Steiner

¹Division of Infectious Diseases, University of Michigan Medical Center, Ann Arbor.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America

|November 1, 1992

Summary

Drug-induced hemolytic anemia can occur with cephalosporins, not just penicillins. A patient developed this condition with cefotetan, indicating a need for broader awareness of cephalosporin-induced hemolytic reactions.

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Area of Science:

Hematology
Immunology
Pharmacology

Background:

Immune hemolytic anemia is often linked to drug-adsorption mechanisms, particularly with penicillins and first-generation cephalosporins.
Drug-induced hemolytic anemia (DIHA) presents a diagnostic challenge, requiring careful consideration of medication history.

Observation:

A case of anemia in a patient receiving intravenous cefotetan is presented.
Cefotetan-dependent antibodies were identified in the patient's serum and red blood cell eluate.

Findings:

The red blood cell eluate showed reactivity with cefotetan and, weakly, without the drug, suggesting autoantibody formation.
Clinical and laboratory findings indicated extravascular hemolysis consistent with DIHA.

Implications:

Related Experiment Videos

This case highlights that cefotetan, a second-generation cephalosporin, can induce hemolytic anemia.
Increased clinical awareness of potential hemolytic reactions to all cephalosporins is crucial for timely diagnosis and management.