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C-type natriuretic peptide in bovine chromaffin cells. The regulation of its biosynthesis and secretion
K Babinski1, J Féthière, M Roy
1Department of Pharmacology, Faculty of Medicine, University of Montréal, Qué, Canada.
FEBS Letters
|November 30, 1992
Abstract:
We report here the regulation of the biosynthesis and the secretion of C-type natriuretic peptide (CNP) in cultured bovine chromaffin cells. The combined treatment with protein kinase A and -C activators induced a 6-fold increase of intracellular levels of CNP-(1-103). The biosynthesized CNP-(1-103) was co-released with its mature forms, typically CNP-(51-103), upon stimulation by nicotine or depolarizing agents. This confirms the neuropeptidic character of this third member of the natriuretic peptide family, which might act as a neuromodulator or neurotransmitter.