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Updated: Oct 20, 2026

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
Published on: August 22, 2016
[Scar tissue in the skin]
Misk Ghassan Farik Muhammad1, Peter Stemann Andersen1, Peter Viktor Vester-Glowinski1
1Afdeling for Plastikkirurgi og Brandsårsbehandling, Københavns Universitetshospital - Rigshospitalet.
Abstract:
Cutaneous scarring after trauma, surgery, or burns is common and may cause pain, pruritus, contracture, and psychosocial distress. This review outlines current evidence, emphasizing meticulous surgical technique, silicone therapy, and photoprotection in prevention. For established scars, silicone, corticosteroids, and laser therapy are first-line options, while pressure garments remain central in burn care. The Patient and Observer Scar Assessment Scale enables structured assessment, and surgery should be reserved for patients with significant functional or cosmetic impairment. Correct referral pathways and nationally standardized care are recommended.
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