Related Experiment Video
Updated: May 5, 2026
08:56
Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
56.6K
Sclerosing cholangitis associated with multifocal fibrosis: a case report
R D Laitt1, S G Hubscher, J A Buckels
1Liver Unit, Queen Elizabeth Medical Centre, Edgbaston, Birmingham.
Gut
|October 1, 1992
Summary
This study presents a rare case of fibrotic overlap syndrome involving sclerosing cholangitis, retroperitoneal fibrosis, and Riedel's thyroiditis. Treatment with surgery and steroids effectively halted disease progression, suggesting an immune basis for this condition.
Area of Science:
- Immunology
- Gastroenterology
- Endocrinology
Background:
- The fibrotic overlap syndrome involves sclerosing cholangitis, retroperitoneal fibrosis, and Riedel's thyroiditis.
- Previous reports successfully managed this triad with steroids.
Observation:
- A new case presented with this rare triad of organ involvement.
- The patient underwent a combination of surgical intervention and steroid therapy.
Findings:
- The combined treatment successfully arrested the progression of the fibrotic disease.
- This outcome supports the hypothesis of an aberrant immune response.
Implications:
- This case highlights the potential efficacy of immunosuppressive therapy in managing complex fibrotic conditions.
- Further research into the immunological underpinnings of fibrotic overlap syndromes is warranted.
More Related Videos
Related Concept Videos
01:17Chronic Bowel Disorders: Introduction
906
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
906
01:24Chronic Pancreatitis I: Introduction
918
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
918
01:23Cirrhosis I: Introduction
30
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
30
01:24Cirrhosis II: Pathophysiology
49
Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to...
49
01:20Cholecystitis
32
Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
32
01:25Chronic Pancreatitis I: Introduction
27
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
27