Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Porous polyurethane vascular prostheses with variable compliances.

S Q Liu1, M Kodama

  • 1Biomaterial Laboratory, Research Institute for Polymers and Textiles, Ibaraki, Japan.

Journal of Biomedical Materials Research
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erythrocyte-to-plasma distribution ratio of cyclosporine: a useful indicator to predict cyclosporine pharmacokinetics and physiological changes during cyclosporine monitoring.

Transplantation proceedings·1996
Same author

Clinicopathological features of multiple primary gastric carcinoma.

Journal of surgical oncology·1996
Same author

Protective effect of a prostaglandin I2 analogue on grafted livers subjected to in situ warm ischemia in porcine orthotopic liver transplantation: immunohistochemical analysis of thrombomodulin.

Transplantation proceedings·1996
Same author

[TNF-alpha gene therapy for nonimmunogenic tumor using immunogenic variant induced with mutagen (N-methyl-N'-nitro-N-nitrosoguanidine)].

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology·1996
Same author

Clinical significance of DNA ploidy pattern in stage III gastric cancer.

World journal of surgery·1996
Same author

Analysis of heart-infiltrating T-cell clonotypes in experimental autoimmune myocarditis in rats.

Circulation research·1996
Same journal

Optimizing the tensile properties of polyvinyl alcohol hydrogel for the construction of a bioprosthetic heart valve stent.

Journal of biomedical materials research·2002
Same journal

Wear of conventional and cross-linked ultra-high-molecular-weight polyethylene acetabular cups against polished and roughened CoCr femoral heads in a biaxial hip simulator.

Journal of biomedical materials research·2002
Same journal

Immobilization of natural macromolecules on poly-L-lactic acid membrane surface in order to improve its cytocompatibility.

Journal of biomedical materials research·2002
Same journal

Light scattering and in vitro biocompatibility studies of poly (vinyl pyrrolidone) derivatives with amino-acid-dependent groups.

Journal of biomedical materials research·2002
Same journal

Immobilization of an oxalate-degrading enzyme on silicone elastomer.

Journal of biomedical materials research·2002
Same journal

An evaluation of the cytotoxic effects of orthodontic bonding adhesives upon a primary human oral gingival fibroblast culture and a permanent, human oral cancer-cell line.

Journal of biomedical materials research·2002
See all related articles

Researchers developed a new method to create porous vascular prostheses using polyurethane. This technique allows easy control over pore size and compliance, crucial for effective tissue ingrowth and matching natural blood vessels.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Vascular Surgery

Background:

  • Vascular prostheses are crucial for replacing damaged or diseased blood vessels.
  • Current prostheses often face challenges with biocompatibility and mechanical matching to native vessels.
  • Developing materials with controlled porosity and mechanical properties is essential for improved graft performance.

Purpose of the Study:

  • To investigate a novel technique for preparing porous vascular prostheses.
  • To explore the influence of processing parameters on the properties of polyurethane-based vascular grafts.
  • To assess the suitability of the fabricated prostheses for tissue ingrowth and vascular implantation.

Main Methods:

  • Polyurethane solutions (5-15 wt%) were injected into molds.

Related Experiment Videos

  • Samples were frozen at temperatures ranging from 0°C to -196°C.
  • Solvents were subsequently leached out using water at 0°C to form porous tubes.
  • Heat treatment was employed to modify graft compliance.

    • Main Results:

    • The technique successfully produced porous tubes with controllable average pore sizes (several microns to 70 microns).
    • Pore occupation ranged from 10% to 51%, and compliance varied from 3% to 35%.
    • Adjusting polyurethane concentration, freezing temperature, and freezing methods allowed for easy modification of pore size and compliance.
    • Heat treatment effectively reduced graft compliance.
    • The method yielded pore sizes (30-60 microns) suitable for tissue ingrowth and compliance matching native arteries and veins.

    Conclusions:

    • A new, versatile technique for fabricating porous polyurethane vascular prostheses has been established.
    • This method offers precise control over critical graft parameters like pore size and compliance.
    • The developed prostheses show promise for artificial implantation, potentially improving outcomes in vascular surgery.