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Related Concept Videos

Applications of Integration to Find Blood Flow01:27

Applications of Integration to Find Blood Flow

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Blood flow through a cylindrical blood vessel can be mathematically described using the principles of laminar flow, a regime in which fluid moves smoothly in parallel layers. In this model, the velocity of the blood is not uniform across the cross-section of the vessel; rather, it varies with the radial distance from the center. The maximum velocity occurs along the central axis, decreasing progressively toward the vessel walls, where it reaches zero due to viscous drag.Approximating Blood...
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Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

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Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
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Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

246
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
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Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters00:54

Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters

460
The noncompartmental approach is a widely used method in pharmacokinetics to assess drugs' behaviors in the body. It considers several factors, including clearance, bioavailability, and total volume of distribution.
One key aspect of the noncompartmental approach is determining a drug's total clearance. This can be done by dividing the drug dose by the area under the concentration-time curve from zero to infinity. The area under the concentration-time curve represents the drug's...
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Wave Parameters01:10

Wave Parameters

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The simplest mechanical waves are associated with simple harmonic motion and repeat themselves for several cycles. These simple harmonic waves can be modeled using a combination of sine and cosine functions. Consider a simplified surface water wave that moves across the water's surface. Unlike complex ocean waves, in surface water waves, water moves vertically, oscillating up and down, whereas the disturbance of the wave moves horizontally through the medium. If a seagull is floating on the...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Purification and characterization of a novel growth factor (FF-GF) synthesized by a rat hepatoma cell line, FF101.

Biochemical and biophysical research communications·1992
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Hyperthermo-chemo-radiotherapy as a definitive treatment for patients with early esophageal carcinoma.

American journal of clinical oncology·1992
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The 11q- syndrome with mosaic partial deletion of 11q.

Acta paediatrica Japonica : Overseas edition·1992
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[Basic and clinical studies on cefprozil in pediatrics].

The Japanese journal of antibiotics·1992
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Preoperative hyperthermia combined with chemotherapy and radiotherapy for patients with rectal carcinoma may prevent early local pelvic recurrence.

International journal of colorectal disease·1992
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Effect of intra-aortic balloon pumping after cardiac surgery: comparative study of use in coronary bypass and valve replacement.

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[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

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Related Experiment Video

Updated: Feb 9, 2026

Optimization of Flow Cytometric Sorting Parameters for High-Throughput Isolation and Purification of Small Extracellular Vesicles
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Optimization of Flow Cytometric Sorting Parameters for High-Throughput Isolation and Purification of Small Extracellular Vesicles

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[Progress and application of multiple-parameter flow cytometric analysis].

H Matsuda1, H Yagita

  • 1Department of Immunology, Juntendo University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|October 1, 1992
PubMed
Summary
This summary is machine-generated.

Advancements in flow cytometry, including new dyes and antibodies, allow for detailed cell analysis. This enables precise characterization and isolation of specific cell populations for research and clinical applications.

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Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes
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Related Experiment Videos

Last Updated: Feb 9, 2026

Optimization of Flow Cytometric Sorting Parameters for High-Throughput Isolation and Purification of Small Extracellular Vesicles
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Flow Cytometric Analysis of Multiple Mitochondrial Parameters in Human Induced Pluripotent Stem Cells and Their Neural and Glial Derivatives
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Area of Science:

  • Biotechnology
  • Cell Biology
  • Immunology

Context:

  • Flow cytometry is a widely used technique in clinical and fundamental research.
  • The development of monoclonal antibodies and fluorescence dyes has significantly advanced the field.
  • Progress in hardware has enabled more sophisticated analyses.

Purpose:

  • To highlight the advancements in multiple-parameter flow cytometry.
  • To explain how new technologies facilitate detailed cell analysis.
  • To underscore the capability for fine characterization of cells.

Summary:

  • Multiple-parameter flow cytometry utilizes advanced monoclonal antibodies and fluorescence dyes.
  • Simultaneous analysis of multiple markers, including intracellular events like Ca2+ concentration and cell cycle, is now possible.
  • High-resolution and sensitive flow cytometers allow for the isolation of unique cell populations.

Impact:

  • Enables fine characterization of cells of interest, even with limited cell numbers and shorter analysis times.
  • Facilitates the isolation of diverse and unique cell populations not achievable through other methods.
  • Supports progress in various clinical and fundamental research fields through enhanced cellular analysis.