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Related Experiment Videos

Strain and sex differences in amphetamine-induced rotation.

H J Storrie-Baker1, M F Novotny, D P Crowne

  • 1Department of Psychology, University of Waterloo, Ontario, Canada.

Pharmacology, Biochemistry, and Behavior
|November 1, 1992
PubMed
Summary

Female Long-Evans rats exhibit greater amphetamine-induced rotation than males, with a significant leftward bias. This contrasts with previous studies, highlighting strain-specific lateralization in rotational behavior.

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Area of Science:

  • Neuroscience
  • Animal Behavior
  • Pharmacology

Background:

  • Rotational behavior in rats is a common model for studying lateralized brain function.
  • Previous research has identified strain-specific differences in rotational behavior, particularly in response to amphetamine.
  • Limited data exists on amphetamine-induced rotation in the Long-Evans hooded rat strain, especially regarding sex differences.

Purpose of the Study:

  • To investigate amphetamine-induced rotational preference in Long-Evans hooded rats.
  • To compare the rotational magnitude and direction between female and male rats of this strain.
  • To determine if strain is a critical factor in the lateralization of rotational behavior.

Main Methods:

  • Long-Evans hooded rats (females and males) were administered amphetamine.

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  • Rotational behavior (magnitude and direction) was quantified.
  • Data was analyzed to compare rotational patterns between sexes and against previous strain data.

    • Main Results:

    • Female Long-Evans rats showed significantly greater rotational behavior compared to males.
    • Contrary to some prior studies, female rats exhibited a significant leftward rotational bias, while males did not show a significant directional preference.
    • The findings indicate a strain-specific lateralization pattern in amphetamine-induced rotation.

    Conclusions:

    • Amphetamine-induced rotational behavior in Long-Evans rats differs from other commonly studied strains.
    • Sex differences in rotational behavior are strain-dependent, with females showing greater rotation and a specific directional bias.
    • The study underscores the critical role of genetic background (strain) in the observed lateralization of neurobehavioral responses.