Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dolichol: a curriculum cognitionis.

F W Hemming1

  • 1Department of Biochemistry, Queen's Medical Centre, University of Nottingham, U.K.

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hints to Consumptives.

Atlanta medical and surgical journal·2022
Same author

The effect of tunicamycin on prostacyclin (PGI(2)) receptors of neuronal hybrid cells.

Neurochemistry international·2010
Same author

Phorbol ester induces a transient increase in alpha(5)beta(1)-mediated adhesion of the megakaryoblastic cell line CHRF 288-11.

Platelets·2006
Same author

The effect of PMA-induced differentiation on the surface expression of integrins on CHRF 288-11 megakaryoblastic cells in culture.

Platelets·2006
Same author

Galactofuranoic-oligomannose N-linked glycans of alpha-galactosidase A from Aspergillus niger.

European journal of biochemistry·2001
Same author

The effect of pH on glucoamylase production, glycosylation and chemostat evolution of Aspergillus niger.

Biochimica et biophysica acta·2001
Same journal

Reply to the discussion of "Efficacy of lactoferrin supplementation in pediatric infections: a systematic review and metanalysis".

Biochemistry and cell biology = Biochimie et biologie cellulaire·2026
Same journal

Discussion of "Efficacy of lactoferrin supplementation in pediatric infections: a systematic review and meta-analysis".

Biochemistry and cell biology = Biochimie et biologie cellulaire·2026
Same journal

Does the beta subunit of mitochondrial trifunctional protein modulate monolysocardiolipin acylation to cardiolipin?

Biochemistry and cell biology = Biochimie et biologie cellulaire·2026
Same journal

Distinct effects of disease-associated mutations in the proximal C-linker on negatively cooperative binding of cyclic nucleotides to the human HCN4 channel.

Biochemistry and cell biology = Biochimie et biologie cellulaire·2026
Same journal

PPP2R2B targets the JAK2-STAT3 signaling pathway to regulate ferroptosis in breast cancer cells.

Biochemistry and cell biology = Biochimie et biologie cellulaire·2026
Same journal

Suppression of CBP/p300 induces growth inhibition and autophagy of hepatocellular carcinoma cells through regulation of EPHA2 by its super-enhancer acetylation.

Biochemistry and cell biology = Biochimie et biologie cellulaire·2026
See all related articles

Dolichols, essential polyisoprenoid alcohols in eukaryotes, are vital cofactors in protein N-glycosylation. Their phosphate derivatives regulate this crucial cellular process, with pathway disruptions linked to disease.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Dolichols are long-chain polyisoprenoid alcohols found in all eukaryotic organisms.
  • Initially identified as ubiquinone precursors, their broader functions were later elucidated.

Observation:

  • Dolichols and related polyisoprenoid alcohols are abundant in plant tissues.
  • Bactoprenyl phosphates' role in bacterial cell wall synthesis suggested a similar function for dolichol phosphates.

Findings:

  • Dolichol mono- and di-phosphates act as essential cofactors in protein N-glycosylation.
  • Glycosylated dolichol derivatives serve as key intermediates in this pathway.
  • Protein N-glycosylation can be controlled by regulating dolichyl phosphate concentration via enzyme activity.

Related Experiment Videos

Implications:

  • Aberrations in dolichol phosphate biosynthesis and metabolism are implicated in various disease conditions.
  • Understanding dolichol phosphate pathways offers potential therapeutic targets for related diseases.