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Rat liver lysosome membranes are enriched in alpha-tocopherol
C A Rupar1, S Albo, J D Whitehall
1Department of Biochemistry, University of Western Ontario, London, Canada.
Abstract:
The subcellular distribution of alpha-tocopherol has been studied in rat liver. Lysosomal membranes were found to be considerably enriched in alpha-tocopherol with 6300 pmol/mg membrane protein, whereas mitochondrial membranes and microsomes contained 530 and 200 pmol/mg membrane protein, respectively. The 37-fold higher specific content of alpha-tocopherol in lysosomal membranes relative to homogenate indicates that lysosomes could be a target of cellular pathology in vitamin E deficiency states.