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Temperature change: the basic variable in the early handling phenomenon?

T SCHAEFER, F S WEINGARTEN, J C TOWNE

    Science (New York, N.Y.)
    |January 5, 1962
    PubMed
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    Early life handling or cold exposure in rats significantly reduces adrenal ascorbic acid levels when stressed. Lowering body temperature during this critical period appears to be the key factor influencing this stress response.

    Area of Science:

    • Physiology
    • Developmental Biology
    • Stress Response

    Background:

    • Early life experiences can profoundly impact an organism's physiological development and stress reactivity.
    • The adrenal ascorbic acid response is a key indicator of the hypothalamic-pituitary-adrenal (HPA) axis activity during stress.

    Purpose of the Study:

    • To investigate the long-term effects of early life handling and cold exposure on the stress response in rats.
    • To determine if temperature reduction, independent of tactile stimulation, influences the adrenal ascorbic acid depletion under stress.

    Main Methods:

    • Rats were subjected to handling or cold exposure (without handling) during the first week of life.
    • Control groups received no early life intervention.
    • Adrenal ascorbic acid levels were measured in stressed and non-stressed adult rats.
    Keywords:
    ADRENAL GLANDS/chemistrySTRESSTEMPERATUREVITAMIN C/chemistry

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    Main Results:

    • Rats exposed to early life handling showed a significant reduction in adrenal ascorbic acid when stressed compared to controls.
    • Rats exposed to cold temperatures without handling also exhibited a significant reduction in adrenal ascorbic acid under stress.
    • Control rats did not display this significant reduction.

    Conclusions:

    • Early life exposure to either handling or cold, which lowers body temperature, primes rats for an altered adrenal ascorbic acid response to stress.
    • Temperature reduction during the neonatal period may be a critical component mediating the effects of handling on the stress axis development.