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Related Experiment Videos

Tadalafil.

Monique Curran1, Gillian Keating

  • 1Adis International Limited, Auckland, New Zealand. demail@adis.co.nz

Drugs
|September 23, 2003
PubMed
Summary
This summary is machine-generated.

Tadalafil effectively treats erectile dysfunction (ED) in men, including those with diabetes. On-demand tadalafil significantly improved erectile function and sexual intercourse success compared to placebo, with generally mild side effects.

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Area of Science:

  • Pharmacology
  • Urology
  • Men's Health

Background:

  • Erectile dysfunction (ED) affects men of all severities, including those with diabetes mellitus.
  • Phosphodiesterase type 5 (PDE5) inhibitors are a common treatment for ED.

Purpose of the Study:

  • To evaluate the efficacy and safety of on-demand tadalafil in men with mild-to-severe ED.
  • To assess tadalafil's impact on erectile function and sexual intercourse success.

Main Methods:

  • A 12-week trial comparing on-demand tadalafil (10 or 20 mg) to placebo.
  • Efficacy assessed using the International Index of Erectile Function (IIEF) and a Global Assessment Question.
  • Adverse events were recorded and analyzed.

Main Results:

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  • Tadalafil significantly improved erectile function domain scores on the IIEF compared to placebo.
  • A higher percentage of successful sexual intercourse attempts was observed with tadalafil.
  • Adverse events like headache and dyspepsia were mostly mild to moderate and decreased over time.

Conclusions:

  • On-demand tadalafil is effective for treating mild-to-severe ED, including in men with diabetes.
  • Tadalafil demonstrates a favorable safety profile with generally mild and transient adverse events.
  • Cardiovascular event incidence did not differ between tadalafil and placebo groups.