Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Simian AIDS: an historical perspective.

M B Gardner1

  • 1Center for Comparative Medicine and California National Primate Research Center, Davis, CA 95616, USA. mbgardner@ucdavis.edu

Journal of Medical Primatology
|September 23, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The intracytoplasmic domain of the Env transmembrane protein is a locus for attenuation of simian immunodeficiency virus SIVmac in rhesus macaques.

Journal of virology·2000
Same author

Simian immunodeficiency virus rapidly penetrates the cervicovaginal mucosa after intravaginal inoculation and infects intraepithelial dendritic cells.

Journal of virology·2000
Same author

The kinetics of specific immune responses in rhesus monkeys inoculated with live recombinant BCG expressing SIV Gag, Pol, Env, and Nef proteins.

Virology·2000
Same author

Immunogenicity of a vaccine preparation representing the variable regions of the HIV type 1 envelope glycoprotein.

AIDS research and human retroviruses·2000
Same author

Hypervariable epitope constructs representing variability in envelope glycoprotein of SIV induce a broad humoral immune response in rabbits and rhesus macaques.

AIDS research and human retroviruses·1998
Same author

Partial body weight support with treadmill locomotion to improve gait after incomplete spinal cord injury: a single-subject experimental design.

Physical therapy·1998
Same journal

Hematology and Serum Biochemistry Reference Intervals for Captive-Born Owl Monkeys (Aotus nancymae): Effects of Age and Sex.

Journal of medical primatology·2026
Same journal

Application of Mobile 3D C-Arm Technology for Diagnostic Imaging of Cleft Palate in an Adult Rhesus Macaque (Macaca mulatta).

Journal of medical primatology·2026
Same journal

Current Landscape of Neonatal/Infant HIV Research: Preclinical and Translational Perspectives.

Journal of medical primatology·2026
Same journal

Clinical Management of Helicobacter Infection in Captive Baboons (Papio anubis and Papio hamadryas), and Isolation and Molecular Characterization of Three Novel Helicobacter Species.

Journal of medical primatology·2026
Same journal

Vitamin D Levels in Captive Bonnet Macaques.

Journal of medical primatology·2026
Same journal

Evaluation of a Point-of-Care Viscoelastic Coagulation Monitor (VCM Vet) and Thromboelastography (TEG) in Bonobos (Pan paniscus).

Journal of medical primatology·2026
See all related articles

Retrovirus research, including studies on simian immunodeficiency virus (SIV), preceded and followed the discovery of acquired immunodeficiency syndrome (AIDS). The simian model of AIDS offers crucial insights into human AIDS pathogenesis and potential interventions.

Area of Science:

  • Retroviral research
  • Primate models in infectious disease
  • Immunodeficiency virus studies

Background:

  • The field of retrovirus research has a 35-year history, encompassing the period before and after the identification of acquired immunodeficiency syndrome (AIDS) in humans, felines, and simians.
  • The emergence of human AIDS was unexpected, yet precursor signs were observable in captive macaques for approximately a decade prior.

Observation:

  • Captive macaques exhibited precursor signs of AIDS for at least ten years before the human disease was identified.
  • The scientific community's knowledge and prevailing mindset during the critical period leading up to AIDS discovery are examined.

Findings:

  • The simian model of AIDS has been instrumental in advancing scientific understanding of the disease.
  • Key contributions from retrovirus research and primate studies have been identified.

Related Experiment Videos

Implications:

  • Understanding the history of retrovirus research and primate models is crucial for addressing current and future viral threats.
  • The simian AIDS model continues to be a vital tool for investigating AIDS pathogenesis and developing therapeutic strategies.