Related Experiment Video

Updated: Aug 31, 2026

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models
12:01

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models

Published on: January 12, 2015

[Role of PPARgamma in the development of the central nervous system]

Koichiro Wada1, Yoshinori Kamisaki

  • 1Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Japan. kwada@dent.osaka-u.ac.jp

Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
|September 23, 2003
PubMed

Insights

Peroxisome proliferator-activated receptor gamma (PPARgamma) is crucial for early central nervous system development. Its activation promotes neural stem cell growth, while inhibition leads to apoptosis, highlighting its role in embryonic brain development.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Developmental Biology

Context:

  • Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear receptor primarily known for its roles in adipocyte differentiation and insulin sensitivity.
  • Emerging evidence suggests diverse functions of PPARgamma in various cell types and organs, prompting investigation into its role in the central nervous system.

Purpose:

  • To investigate the role of PPARgamma in the development of the murine central nervous system.
  • To examine the effect of PPARgamma ligands and antagonists on neural stem cells (NSCs) isolated from embryonic mouse brains.

Summary:

  • PPARgamma expression is low in adult mouse brains but high in embryonic and fetal brains.
  • PPARgamma-specific ligands stimulated proliferation and growth of murine embryonic neural stem cells.
  • PPARgamma antagonists induced cell death and apoptosis in these neural stem cells.

Impact:

  • These findings suggest that PPARgamma plays a significant role in the early developmental stages of the central nervous system.
  • Understanding PPARgamma's function in neurodevelopment could offer insights into potential therapeutic targets for neurological disorders.

More Related Videos

Derivation of Glial Restricted Precursors from E13 mice08:56

Derivation of Glial Restricted Precursors from E13 mice

Published on: June 20, 2012

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM)09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM)

Published on: May 8, 2020

Related Concept Videos

Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Gut-Brain Axis01:22

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.