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Pre-eclampsia and trisomy 13.

J F Tuohy1, D K James

  • 1Department of Obstetrics, Bristol Maternity Hospital, UK.

British Journal of Obstetrics and Gynaecology
|November 1, 1992
PubMed
Summary
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This study found a significant association between trisomy 13 and maternal pre-eclampsia, particularly in first-time mothers. The findings suggest a fetal role in pre-eclampsia development, possibly linked to chromosome 13 genes.

Area of Science:

  • Reproductive Medicine
  • Genetics
  • Maternal-Fetal Medicine

Background:

  • Pre-eclampsia is a serious pregnancy complication.
  • Trisomy 13 is a chromosomal disorder with significant health implications.
  • The relationship between trisomy 13 and pre-eclampsia is not well-established.

Purpose of the Study:

  • To investigate the association between trisomy 13 and maternal pre-eclampsia.
  • To compare pre-eclampsia incidence in trisomy 13 pregnancies with controls.

Main Methods:

  • Retrospective case-control study design.
  • Involved 25 women with trisomy 13 infants, 38 with trisomy 18 infants, and 50 controls.
  • Analyzed medical records for pre-eclampsia using four thresholds, stratified by parity.

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Main Results:

  • Significantly higher incidence of pre-eclampsia in trisomy 13 pregnancies compared to trisomy 18 and normal karyotype groups.
  • The association was more pronounced in primigravid (first-time) pregnancies.

Conclusions:

  • Suggests a significant association between trisomy 13 and pre-eclampsia.
  • Supports the hypothesis of a fetal factor in pre-eclampsia pathogenesis.
  • Speculates on the role of genes on chromosome 13.