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Related Experiment Videos

Disseminated intravascular coagulation.

Sjoukje H Slofstra1, C Arnold Spek, Hugo ten Cate

  • 1Laboratory of Experimental Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. s.h.slofstra@amc.uva.nl

The Hematology Journal : the Official Journal of the European Haematology Association
|September 23, 2003
PubMed
Summary

Disseminated Intravascular Coagulation (DIC) is a complex hypercoagulable state. Activated neutrophils are key in DIC

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Area of Science:

  • Hematology
  • Pathophysiology
  • Critical Care Medicine

Background:

  • Disseminated Intravascular Coagulation (DIC) is an acquired hypercoagulable state with hemorrhagic symptoms and organ failure.
  • Diagnosing DIC is challenging, often difficult to distinguish from underlying conditions.
  • DIC involves enhanced inflammation, coagulation, and impaired fibrinolysis, particularly in sepsis models.

Purpose of the Study:

  • To review the pathophysiology of DIC, focusing on the role of activated neutrophils.
  • To explore potential avenues for improved diagnostic tools and therapeutic strategies for DIC.

Main Methods:

  • Review of experimental studies, particularly those using gram-negative sepsis and Generalized Shwartzman Reaction models.
  • Analysis of molecular interactions in the onset and progression of DIC.

Main Results:

  • Activated neutrophils are proposed to play a pivotal role in DIC pathophysiology, contributing to inflammation and vascular injury.
  • Granulocytes may also have a distinct role in fibrinolysis.
  • Current therapies targeting DIC pathways have shown limited success, except for activated protein C.

Conclusions:

  • Understanding the molecular mechanisms of DIC is crucial for developing better diagnostic and therapeutic options.
  • Targeting neutrophil activation and inflammatory pathways may offer future therapeutic strategies for DIC.

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