[Effect of paleocerebellar cortex electrical stimulation on generalized penicillin-induced seizure activity in rats]

It was shown that low-frequency electrical stimulation (ES) (10-12 Hz, 0.5 ms) of paleocerebellar cortex (nodulus, uvula) is followed by activation of spike discharges which were induced via i.p. administration of sodium benzilpenicillin salt to alert Wistar rats (300,000 IU/kg). The facilitation of ictal discharges generation was also seen in the course of such an ES. High-frequency (100-300 Hz, 0.25 ms) ES of the same structure was followed by suppression of spike discharges and prevented the ictal discharges precipitation. Antiseizure action was obvious under condition of relatively low level of epileptic activity generation. In the course of such ES the decreasing frequency and amplitude of spike discharges were noted during interstimuli periods. Besides, the life-span of seizure activity was shortened as well. The repeated paleocerebellar ES made after electrocoagulation of irritated tissue did not cause modulations of seizure activity.